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14-3-3 inhibitor BV2
CAS No. 302602-92-2
14-3-3 inhibitor BV2( —— )
Catalog No. M13948 CAS No. 302602-92-2
A novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name14-3-3 inhibitor BV2
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NoteResearch use only, not for human use.
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Brief DescriptionA novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation.
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DescriptionA novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation; induces significant dose-dependent reduction of reproductive integrity of Ba/F3 cells expressing the wt and T315I-mutated Bcr-Abl with LD50 of 1.04 and 1.47 uM, respectively; promoted c-Abl release from 14-3-3σ, abolishes c-Abl expression in the cytoplasm, but has no influence on 14-3-3σ levels, induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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Target14-3-3 Protein
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Recptor14-3-3 Protein
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Research Area——
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Indication——
Chemical Information
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CAS Number302602-92-2
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Formula Weight395.371
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Molecular FormulaC20H17N3O6
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)C3=C(C=CC(=C3)C(=O)O)C(=O)O
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Chemical Name2-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)carbamoyl)terephthalic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mancini M, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):596-604.
2. Mohammad DK, et al. Mol Cell Biol. 2013 Aug;33(16):3214-26.
3. Gómez-Suárez M, et al. Cell Death Differ. 2016 Jun;23(6):1060-72.
4. Valensin D, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):894-898.
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